For most people, ashwagandha is a safe and effective supplement for taking the edge off stress. Staff, Cotellic With Turmeric And Black Pepper Interaction. Melissa Nieves, LND, RD, is a registered dietitian and licensed nutritionist who works as a bilingual telehealth dietitian. In fact, according to the book Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, published in 2010 by the British Psychological Society, there are no specific vitamins contraindicated for consumption with antidepressants. Role of an indigenous drug Geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis. 2013;45(4):417-8. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Historically, ashwagandha has been thought of as a possible stimulant for athletics since the ancient medical system. 2003;19(3):211-222. View abstract. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. However, there is concern that herbs like ashwagandha may have interactions that have . Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. This means they can cause drug-drug interactions, and they can have all the usual side effects and risks that pharmaceutical can have. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. Insomnia is a common sleep disorder that is defined as an inability to get adequate sleep. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. You can also connect with Dr. Brian Staiger on LinkedIn. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Nonetheless, additional large-scale, long-term studies would strengthen these findings. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. metoprolol, nebivolol, propranolol), Diuretics (e.g. View abstract. Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. However, many studies supporting the use of ashwagandha are small or poorly designed. For more information on drug interactions, visit the RxList Drug Interaction Checker. This article provides a review of the potential uses of ashwagandha. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Durg S, Bavage S, Shivaram SB. Animal research and one case study indicate that the herb might increase serum concentration of thyroid hormones, according to Ray Sahelian, a medical doctor who specializes in natural supplements. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. Take extra care and check with your doctor if you have: Signs of a very bad reaction. Ashwagandha might increase how much thyroid hormone the body produces. Supplements that are similar to ashwagandha include: It's typically best to take just one supplement or herb at a time for a medical condition. It also covers possible side effects of the herb, interactions, dosage information, and guidance regarding selecting ashwagandha supplements. Safety and adverse events were also not well-reported in the studies used in the review. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. 1998;20(1):191-198. 2019;98(37):e17186. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have. PLoS One. It may also interact with other herbs, supplements, and even foods. Ashwagandha for Thyroid Health - Thyroid Advisor Side Effects Of Ashwagandha: 5 Things To Be Aware Of - CureJoy View abstract. 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. The liver damage never progressed to liver failure, and most cases were resolved within five months. 8-19-2005;334(1):276-287. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Read our. Tumori 8-31-1994;80(4):306-308. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. Drug Interaction Checker - Find Interactions Between Medications - WebMD People using ashwagandha for physical performance may need to take higher doses of up to 1,250 milligrams daily to see benefits. J Ethnopharmacol. Dasgupta A, Peterson A, Wells A, Actor JK. Talk with a healthcare provider about the right ashwagandha dosage for your needs. Available for Android and iOS devices. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. Study participants were randomized to receive a placebo, 225 milligrams per day of ashwagandha, or 400 milligrams per day of ashwagandha for 30 days. This information may not fit your specific health circumstances. Indian J Physiol Pharmacol. Biogerontology. Ashwagandha might cause sleepiness and drowsiness. 2019;11(10):2362. doi:10.3390/nu11102362, Zhu C, Zhang Y, Wang T, et al. However, these results have not been proven in humans. As this is a relatively new area of research, more vigorous studies are needed. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. Is this an emergency? Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. J Res Ayur Sid 1980;1:370-385. According to the Mayo Clinic, all of these SSRIs work by blocking the reuptake of serotonin in the brain, which essentially makes serotonin more available. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. View abstract. View abstract. Some benzodiazepine drugs include alprazolam, known as the brand Xanax; clonazepam, known as Klonopin; diazepam, known as Valium; lorazepam, known as Ativan; and triazolam, known as Halcion. In the study, no adverse events were reported by participants who took the herb. Antidepressants come in various forms. Phytotherapy Research 1989;3(5):201-206. Ashwagandha can also interact with some medications and affect how they work. In rare cases, the use of ashwagandha may lead to liver damage. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. 2020;34(5):1041-1059. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. Expert Rev Clin Pharmacol. Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. Hydroxyzine has moderate interactions with at least 207 different drugs. blood glucose). Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. View abstract. However, even if supplements are third-party tested, they are necessarily safe for all or effective in general. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. View abstract. Those who took 600 milligrams per day of ashwagandha had better results than those in the 250 milligrams per day group, yet both groups saw improvements in stress. The length of use of ashwagandha ranged from 14 to 110 days, and doses ranged from 450 milligrams to 1,350 milligrams per day. Read more: 8 Warning Signs of Depression You Shouldn't Ignore. Nutrients. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. However, tyramine-rich foods like cheeses, beer and other fermented products are dangerous for people taking MAOIs. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. Hi, I was recommended to take ashwagandha. In recent years, some researchers have assessed how ashwagandha may benefit physical performance. Ashwagandha is popular in Ayurveda medicine, and Indians have used it for more than 3,000 years to treat a wide range of healthy disorders. Immunopharmacol.Immunotoxicol. Take ashwagandha with these drugs only under your doctor's supervision, recommends the Langone Medical Center at New York University. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Is It Safe To Take Keflex (Cephalexin) With Birth Control? According to their lab study, withanone may interfere with DNA, leading to liver damage. Learn which supplements can interact with thyroid hormone medications like levothyroxine (Synthroid), thyroid hormone levels, and laboratory tests. low blood sugar). 2020;40(4):825-829. View abstract. 2005 - 2023 WebMD LLC, an Internet Brands company. However, there is concern that herbs like ashwagandha may have interactions that have not yet been identified. J Ethnopharmacol. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. Long-term safety studies on ashwagandha are lacking. View abstract. The comparative effect of milk fortified with Aswagandha, Aswagandha and Punarnava in children - a double-blind study. Ghosal S, Lal J, Srivastava R, and et al. Lower ashwagandha doses of 225 milligrams per day to 400 milligrams per day have been associated with perceived improvements in stress and anxiety. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. Most ashwagandha supplements are naturally vegan and gluten-free. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Harvard Health Publishing states that other medications, supplements and your diet all have the potential to affect the way your body processes your antidepressants. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. Be sure to tell your doctor if you are breastfeeding. Third-party agencies like these confirm that supplements actually contain what they say they do, but they do not approve medical claims. View abstract. However, the review noted various limitations of the studies, including study design and potential bias. Indian J Exp Biol. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. While supplement and drug-induced serotonin syndrome poses a major risk for people taking SSRIs, other antidepressants can require stricter dietary changes. As with many other herbal supplements, little research is available on possible interactions. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. . A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. 2001;75(2-3):165-168. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. Go to the ER right away. Which Supplements Should Be Avoided When Taking Statins View abstract. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. J Ayurveda Integr Med. The April 2008 issue of "Therapeutic Drug Monitoring" notes that some herbal products interfere with methodology used to measure drug levels in a patient's bloodstream. 2020;12(4):1119. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. J.Transl.Med. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. View abstract. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Serotonin syndrome can even result in death. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Ashwagandha has mild interactions with at least 29 different drugs. Hidese S, Ogawa S, Ota M, et al. A total of 203 drugs are known to interact with levothyroxine . No supplement is intended to treat, cure, or prevent disease. Does Ashwagandha Interact With Any Medications? 2021;2021:8254344. doi:10.1155/2021/8254344, Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs. View abstract. This is called a medicine interaction. If you're taking antidepressants and vitamins at the same time, be aware of the ingredients in your vitamin supplements. Ashwagandha interacts with 623 drugs. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Ashwagandha Dosage: How Much Ashwagandha Per Day? - Healthgrades View abstract. Effect of Ashwagandha (Withania somnifera Dunal) on the process of ageing on human volunteers. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Panda S, Kar A. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. 2016;5(4):40. doi:10.3390/antiox5040040, Vitale KC, Hueglin S, Broad E. Tart cherry juice in athletes: a literature review and commentary. View abstract. What are some herbs that are contraindicated with Cotellic (cobimetinib)? Liver Int. The body naturally produces thyroid hormones. Ashwagandha may be able to help with insomnia. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Some people may need to avoid taking Ashwagandha, however, including those who: ASHWAGANDHA: Overview, Uses, Side Effects, Precautions, Interactions View abstract. Food Chem.Toxicol. These side effects are usually experienced on higher doses. Dhuley, J. N. Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice. ashwaganda: Dosing, contraindications, side effects, and - Epocrates 2021;270:113766. J Pharm Pharmacol 1998;50:1065-68. Medicine (Baltimore). Cureus. This product can contain high amounts of iron. Ashwagandha supplements come in various forms, including capsules, gummies, caplets, liquid extracts, and powders. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. Ashwaganda is used to treat Herbal Supplementation. Notably, ashwagandha doses typically do not exceed 1,000 milligrams per day for up to 12 weeks. More are needed for more definitive results. Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. Herbs like Ashwagandha are known to interact with SSRI and other medicines. Ashwagandha: MedlinePlus Supplements Its effect on arterial blood pressure in anaesthetized dogs. View abstract. View abstract. Ashwagandha may interact with various medications. Herb-drug interactions. Is Fish Oil Dangerous With Antidepressants? What to Look for When Choosing Ashwagandha Supplements, Uses of Lavender: Everything You Need to Know, I Tried Taking Ashwagandha and It Gave Me Crazy Vivid Dreams, Natural withanolides in the treatment of chronic diseases, Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects, Potential clinical applications of Ashwagandha (, Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (, An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (, Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study, A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (, Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers, Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network, DNA damage by withanone as a potential cause of liver toxicity observed for herbal products of, Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial, Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency, Vitamin E, turmeric and saffron in treatment of Alzheimer's disease, Tart cherry juice in athletes: a literature review and commentary, Dietary supplements: what you need to know. Ashwagandha may lower blood sugar (i.e. Medical Content Reviewed By HelloPharmacist Some but not all ashwagandha supplements are organic. People who are pregnant or breastfeeding should avoid using the herb, as not enough is known about its safety. Curr Res Toxicol. Fortunately, no cases resulted in liver failure, and all recovered. Its effects on arterial blood pressure in anaesthetized dogs. View abstract. Within this specific study, participants were randomized to receive a placebo (sugar pill with no active ingredients), an ashwagandha dose of 250 milligrams (mg) per day or 600 milligrams per day. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. View abstract. Some of these interactions can be life-threatening. Dasgupta A, Tso G, Wells A. TSH Suppression. View abstract. 4. However, some adverse effects are generally associated with ashwagandha. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. J Funct Morphol Kinesiol. Agarwal R, Diwanay S, Patki P, Patwardhan B. Ashwagandha: Benefits, Side Effects, Dosage, and Interactions Ashwagandha appears to stimulate your endocrine system . Talk with a healthcare provider about which herb or supplement may be best for you. Cent.Nerv.Syst.Agents Med.Chem. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. This means not enough is known about either the safety or effectiveness of taking daily ashwagandha for an extended period of time. J Diet Suppl. Nutrients. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. Health Sci Rep 2022;5(4):e741. View abstract. WebMD does not provide medical advice, diagnosis or treatment. Indian J Med Res 2015 Jan;141(1):100-6. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. J Atten Disord 2010;14:281-91. drugs for diabetes and blood pressure). View abstract. J Evid Based Complementary Altern Med. Ashwagandha: Supplement, Uses, Side Effects, Dosages, Interactions View abstract. 2017 Jan;22(1):96-106 View abstract. Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. J Clin Psychiatry. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. When multiple foods or supplements are processed by your body via the same exact route, they may compete with one another. By Brittany Lubeck, RD Some ontologies are recognized by everyone, diabetes insipidus medication side effects and some are recognized noni lower blood sugar as ontologies only by . When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Ashwagandha might lower blood pressure. Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. Underactive Thyroid. Ashwagandha - Diazepam Interaction Details | HelloPharmacist 1988;26(11):877-882. Myxedema Coma. 2019;11(9):e5797. Again, be sure to talk to your doctor about adding ashwagandha to immunosuppressant drugs. This information does not endorse any treatments or medications as safe, effective, or approved for treating a . Who Shouldn't Take Ashwagandha? Fertil Steril 2010;94:989-96. There is no scientific evidence to support one supplement form over another, which means you should choose the one that best fits your lifestyle. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Brain Behav. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. Use birth control you can trust while taking this product. doi:10.7759/cureus.5797, Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. Nat.Prod.Res 2005;19(6):567-571. All rights reserved. A few commonly prescribed benzodiazepines are: Alprazolam (Xanax) Clonazepam (Klonopin) Diazepam (Valium) Lorazepam (Ativan) Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants.
?>
does ashwagandha interact with medications